The Kwan Lab
We are a chemical and synthetic biology research group at Concordia University, in Montreal, Canada

In the Kwan lab, we specialize in chemical and synthetic biology, with a focus on controlling protein function through strategies such as directed evolution, small-molecule modulation, and manipulation of post-translational modifications (especially glycosylation). Our research spans applied protein science, where we treat proteins as sophisticated molecular machines that can be studied, tuned, and redesigned for diverse purposes. By combining enzyme engineering, high-throughput screening, and chemical tools, we create interconnected approaches that advance both fundamental understanding and real-world applications—from sustainable industrial processes to biomedical innovations.

Team and Projects

DAVID H. KWAN, PH.D.
Professor of Biology, Concordia University
Co-director: Centre of Applied Synthetic Biology (CASB)
PDF University of British Columbia (Chemistry, advisor: S.G. Withers)
Ph.D. University of Cambridge (Biochemistry, advisor: P.F. Leadlay)
B.Sc. (Hons.) University of British Columbia (Biochemistry)
Email: david.kwan@concordia.ca

Dr. Emily Clayton. Postdoctoral Fellow since 2022.
(Ph.D. from Western University)
Research project: Screening small-molecule inhibitors of human fucosyltransferases and directed evolution of bacterial fucosyltransferases.
Email: emily.clayton@concordia.ca
Dr. Paolo Costa. Postdoctoral Fellow since 2023.
(Ph.D. from University of Padua)
Research project: Glycoengineering of antibodies and extracellular vesicles towards advanced biologics.
Email: paolo.costa@concordia.ca


Trisha Ghosh. Ph.D. student since 2020.
(M.Sc. from Concordia University)
Research project: Enzyme cascades for high-throughput screening and protein engineering.
Sara Ouadhi. Ph.D. student since 2021.
(M.Sc. from University College London)
Research project: Enzymes and pathways involved in glycosylated natural product biosynthesis.


Megan Greensill. M.Sc. student since 2025.
(B.Sc. from University of Victoria)
Research project: Screening post-translational modification of monoclonal antibodies.